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One other important result was that patients treated with a single dose of prednisolone were statistically more likely to receive additional doses of the steroid compared to patients treated with 0.05% or 0.001% oral prednisolone (the range for this type of study is 0.02-0.03%). This has important implications: It shows that patients who receive 0.05% oral prednisolone are at particular risk from excessive use of the steroid; patients who are prescribed a single dose of 0.05% prednisolone will be less likely to receive additional doses than those given a single dose of all prednisolone. The dose of 0.05% prednisolone that has been shown to be most effective against H. pylori is also the highest dose (4.7 mg/kg/day) that has been studied. The study results showed that when patients were given 4.7 μg oral prednisolone (0.05%) over one year, the absolute reduction in the incidence of H. pylori infection in patients treated with the prednisolone was about 50%. This means that patients taking the highest dose of prednisolone were about 40% more likely to be free of H. pylori over the course of the study than patients who were treated with a low dose (a single dose of 0.05%). Another important finding was that patients in study 2 who were given the lowest dose of prednisolone for one year were more likely to receive 1 or 2 additional doses compared to patients treated with 2 or more doses over one year (see the table). As to the overall effectiveness of the study of prednisolone for reducing recurrence of H. pylori infection, the researchers concluded that prednisolone is a promising strategy for preventing recurrence in patients at higher risk for having H. pylori: "These findings suggest that a combination of prednisolone and antibiotics is an effective and inexpensive approach to reducing recurrence of H. pylori in patients with an increased risk of acquiring H. pylori infection." The scientists state that they plan to continue their study to see if the effect of combining prednisolone and antibiotics for five to seven years remains significant or if further research is warranted. A second study looking at the effectiveness of combination therapy, which is what they recommend, was just released by the scientists at Johns Hopkins University College of Medicine. They studied patients who developed a new strain (Bacteroides thetaiotaomicron var. bacteroides) of H. pylori over a five-year period. Similar articles:
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